Potentially ideal contraceptive for men


Despite the fact that female contraceptive pills have been around since the middle of the last century, reliable male contraceptives, which are not condoms, have never seen the light of day ...

Creating male contraceptives is especially difficult, and so far we have had only a few safe and effective methods for delivering modified oral testosterone, all of which require men to consume certain doses several times a day. Unfortunately, the contraceptive industry has stopped at the fairer sex, while its products often cause unpleasant hormonal imbalances or invasive surgeries.

In order to stop all this, there was a collaboration between Chinese and American scientists who developed a contraceptive agent that they claim is reversible, non-hormonal and non-toxic, which proved to be equally accurate in tests performed on mice and primates. The new compound looks very promising and with extensive human trials can finally create a contraceptive solution for male disposables.

Tryptonide is still in the developmental stage and has been tested for contraceptive values ​​since the beginning of the millennium, when one study suggested that its composition directly reduces sperm production. Produced from the "wine of the god of thunder", the plant Tripterygium Wilfordii, the tryptonide contraceptive is a clinically relevant ingredient isolated from this plant. The composition of the plant includes triptolid, which has a potential use value in the treatment of kidney disease and pancreatic cancer, followed by triptolidenol, which scientists are investigating for its use in the fight against kidney cell cancer.

The plant, the wine of the god of thunder, was first identified as a contraceptive after reports from 1993, in which it was announced that men who consumed it for other reasons drastically reduced the number of sperm, reduced their motility and deformed their shape. Since then, a number of isolated ingredients of this plant species have been carefully studied as male contraceptives. However, despite the reduction in sperm count in numerous clinical trials, certain isolates are highly toxic for use.

In the latest study, researchers tested tryptonide to get a definitive insight into the safety and efficacy of this ingredient in animal models. This study included mice and twelve adult specimens of male macaque monkeys. After a one-day dose of tryptonids, mice and monkeys eventually experienced 100% deformity of sperm between the third and fourth, and fifth and sixth weeks, respectively, which made them completely infertile. Fertility returned after dosing was stopped between the fourth and sixth week, suggesting that the content of this compound was reversible. Accompanying analyzes of vital organs proved that there are no side effects in animals, which makes tryptonide completely different from other plant isolates in overall toxicity.

Of course, research is still preliminarily based on the study of animals to prove the relevance of the compound, but soon the entire study will require refinement or continuation with human testing, before it is allowed. On the other hand, the result of this research offers hope to all who eagerly await a male contraceptive, either for the purpose of easing and removing the burden from women, or to enable the safety of almost complete protection, without the use of condoms.

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